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Chemical Process Engineer Career Training Guide

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Question: Have scientists Really Created Life from scratch? Is it a higher intelligence rather than natural occurrence? A large team of collaborators recently published papers in Science and in Nature reporting on two enzymes created from scratch and capable of catalyzing nonbiological chemical transformations. This work has several important implications: It helps biochemists to develop a better understanding of the relationship between enzyme structure and function. It also establishes an approach to generate novel enzymes which can have a wide array of practical applications. And finally, it affects attempts by life scientists to create artificial life in the lab, and, consequently, impacts the creation/intelligent design/evolution controversy. Though conceptually easy, designing these two enzymes was no trivial undertaking. The strategy employed by the researchers involved: * Modeling the reaction mechanism and the transition state of the reaction * Determining how to stabilize the transition state by placing chemical groups around the transition state complex * Designing an enzyme active site that yields the proper placement of chemical groups in space * Constructing the scaffolding of the protein chain to form and accommodate the active site * Fine-tuning the resulting enzymes Executing this strategy required a large team of quantum and computational chemists, protein engineers, biochemists, and molecular biologists to create these biomolecules. The computations needed to design the active site and the initial enzyme architectures required hours and hours of supercomputer time. It took so much effort to design the active site and protein scaffold primarily because the computational chemists and protein engineers weren’t able to build the enzymes from first principles. Instead they had to piece together the enzymes from the domains of about 100 proteins of known structure. They essentially mixed and matched protein regions, producing mosaic enzymes. Using this approach, they still had to sort through combinations for about 100,000 different protein regions. Once they created a scaffold that appeared to work, they had to optimize it using computational techniques. For one of the enzymes, this process yielded about 58 candidates. Candidate enzymes were synthesized and evaluated in the lab as catalysts. Of the 58 possibilities only eight performed well enough to take to the next stage. The structures of the best enzymes were then fine-tuned with in vitro evolution protocols. For one of the created enzymes, the in vitro evolution step improved efficiency by about two hundredfold. Still, this enzyme operated with an efficiency that was ten thousand to a billion times less effective than enzymes typically found in living systems. According to the authors: " Although our results demonstrate that novel enzyme activities can be designed from scratch and indicate the catalytic strategies that are most accessible to nascent enzymes, there is still a significant gap between the activities of our designed catalysts and those of naturally occurring enzymes." Even though the created enzymes fall short of those in nature, this advance truly represents a landmark accomplishment that stands as a towering intellectual achievement in every way. The ability to design enzymes that can catalyze novel, nonbiological chemical reactions will lead to better understanding of protein structure and enzyme catalysis. This methodology will also pave the way for protein engineers to design enzymes with industrial, agricultural, and biomedical utility. At first Glance it appears as if scientists are one step closer to creating life in the lab. And if scientists can create life, where does that leave God? In the face of this concern it’s remarkable to note how much effort it took to design a single enzyme that at best compares poorly with those found in nature. It took a collaborative effort from a large number of some of the finest minds in the world to develop and employ an effective design strategy. These researchers relied on sophisticated mathematical algorithms and technology (supercomputers and laboratory instruments) to carry out their scheme. If it takes this much work and intellectual input to create a single enzyme from scratch, is it really reasonable to think that undirected evolutionary processes could routinely accomplish this task? And to a superior extent each time an enzyme emerges in nature? . Acid Zebra... simply by considering the probability of the essential gene set coming into existence simultaneously. According to this analysis, it is super-astronomically improbable for the essential gene set to emerge simultaneously through natural means alone. If left up to an abiogenesis/evolutionary process, not enough resources or time exist throughout the universe’s history to generate life even in its simplest form.

Answer: One day a group of scientists got together and decided that man had come a long way and no longer needed God. So they picked one scientist to go and tell Him that they were done with Him. The scientist walked up to God and said, "God, we've decided that we no longer need you. We're to the point that we can clone people and do many miraculous things, so why don't you just go on and get lost." God listened very patiently and kindly to the man and after the scientist was done talking, God said, "Very well, how about this, let's say we have a man-making contest." To which the scientist replied, "OK, great!" But God added, "Now, we're going to do this just like I did back in the old days with Adam." The scientist said, "Sure, no problem" and bent down and grabbed himself a handful of dirt. God just looked at him and said, "Oh no! You go make your own dirt!"

 


Chemical Process Engineer Career Information and Opportunities

Cramming for Degrees in Hybrids

Pittsburgh Post Gazette
This imposes a collaborative approach on the development process, requiring engineers to work in groups and consider the entire vehicle, not just its individual components. The growing complexity of these vehicles is one reason automakers, ...
 

China's National Institute for Clean-and-Low-Carbon Energy (NICE) Announces ...

MarketWatch (press release)
NICE is staffed with top scientists and engineers from around the world, working in collaboration with international partners to develop breakthrough technologies and associated processes that can be deployed at scale, in the areas of clean and low ...
 

MassLive.com

UMass, Delaware researchers develop low-cost process to make plastic from plants
MassLive.com
 

UM selects Idaho chemical engineer to lead Native research lab

The Missoulian
Following a unique and controversial search process, the University of Montana has selected a new director of its Native American Research Lab. Aaron Thomas, a chemical engineer in the College of Engineering at the University of Idaho, will take over ...
 

China's National Institute for Clean-and-Low-Carbon Energy (NICE) Announces ...

Sacramento Bee
NICE is staffed with top scientists and engineers from around the world, working in collaboration with international partners to develop breakthrough technologies and associated processes that can be deployed at scale, in the areas of clean and low ...
 

Construction begins for chemical-free treatment

Superior Telegram
RJS Construction has started to build the footings for the foundation of a 38-foot by 62-foot building that will eliminate chlorine and sulfur dioxide from the wastewater treatment process as the city converts the disinfection process to ultraviolet ...
 

Agri Process Innovations Starts Up 22nd Biodiesel Plant

Domestic Fuel
In Louisiana, Agri Process Innovations has announced the startup of Oswalt Bioenergy of Lake Providence, Agri's twenty second biodiesel plant opening. Chemical engineer Brian Mattingly led the startup for the Louisiana company. Mattingly said that this ...
 

Nail the "Tell Me About Yourself" Job Interview Question

Lifehacker
"I am a chemical engineer with eight years of experience, four which were in process engineering at Clorox working on improving plant productivity and four in specialty resin chemical sales where I help customers develop new products that improve their ...
 

Senior Process Engineer (contract)

Environmental Expert (press release)
Degree qualified (or equivalent) in Chemical or Process Engineering or other relevant subject. A member of a relevant engineering institution ie IChemE. Experience within the water industry particularly with compliance issues and potable water ...
 

Student-devised process would prep shale gas for sale

R & D Magazine
The CHBE Pandas (CHBE stands for chemical and biomolecular engineering) designed a process by which shale gas extracted in the rich Sichuan Basin could be turned into methanol, hydrogen, and carbon disulfide, all valuable products in the booming ...